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Agenda 2021
DAY 1: TUESDAY, 29 JUNE, 2021
0900 - 0930 REGISTRATION AND MORNING REFRESHMENTS
0930 - 0940 OPENING ADDRESS
0940 - 1010 LEVERAGING PRIVATE PUBLIC PARTNERSHIPS IN COVID-19 PANDEMIC RESPONSE
- International co-operation and global solidarity
- Leverage private public partnership in vaccines development
- Rules need to be set now to manage Intellectual property rights and procurement for equitable access
Anh Wartel
International Vaccine Institute
International Vaccine Institute
1010 - 1040 DEVELOPMENT AND MANUFACTURING COVID-19 VACCINES IN A PANDEMIC SITUATION
- Case study: CEPI’s response to COVID-19
- COVID-19 vaccine global access (COVAX) facility: manufacturing SWAT team activities
Anna Särnefält
CEPI
CEPI
1040 - 1100 MORNING COFFEE BREAK IN EXHIBIT AREA
1100 - 1130 RAPID RESPONSE VACCINE PLATFORMS FOR FUTURE PANDEMICS: CONSIDERATIONS FOR LOW AND MIDDLE-INCOME COUNTRIES (LMICS)
- Several new vaccine platforms have been utilized to develop COVID-19 vaccine candidates
- Intervention Target Product Profiles have been developed to help guide developers with respect to COGs/Pricing, storage requirements, and other key product parameters
- Goal: Review emerging vaccine platforms to assess their potential to address the requirements for LMICs and applicability to future pandemic response
Ajoy Chakrabarti
Bill & Melinda Gates Foundation
Bill & Melinda Gates Foundation
1130 - 1200 DEVELOPMENT AND PRECLINICAL TESTING OF A NOVEL SELF-ASSEMBLING T-CELL VACCINE FOR COVID-19
- Presentation of the VaxCelerate platform developed with US DoD support to address pandemic and emerging infectious diseases
- Preclinical testing of the VaxCelerate platform for Lassa Fever and COVID-19
- Planning for first in human testing of the self-assembling vaccine for COVID-19
Mark Poznansky
Harvard Medical School
Harvard Medical School
1200 - 1330 NETWORKING LUNCH & VISIT VACCINE TECHNOLOGY EXHIBITION
1330 - 1400 WHICH SUGAR DO YOU WANT? ENGINEERING CHO CELLS FOR THE PRODUCTION OF RECOMBINANT PROTEINS WITH TAILOR-MADE GLYCOSYLATION
- High throughput targeted engineering of CHO cells for improved production of recombinant proteins
- Toolbox: 30+ cell lines for quick production of small quantities of glycovariants for screening for optimal glycoform
- Scalable production of the preferred glycovariant from stable and robust production cell line
Bjorn Voldborg
Technical University of Denmark
Technical University of Denmark
1400 - 1430 DEVELOPMENT OF AN AUTOMATED MICROSCALE SCREENING PLATFORM FOR GLYCOCONJUGATE VACCINE PRODUCTION
- Initial scale down using kla estimations and the product expression achieved at two scales
- Development of an automated microscale screening platform
- Results from the screening platform (strain comparison and media formulation)
Jasmin Samaras
University College London
University College London
1430 - 1500 AFTERNOON COFFEE BREAK IN EXHIBIT AREA
1500 - 1530 COMBINING EVOLUTIONARY ENGINEERING WITH PROCESS INTENSIFICATION FOR IMPROVED INFLUENZA HA-VLPS PRODUCTION IN STABLE INSECT CELLS
- Adaptive laboratory evolution of stable insect cells to hypothermic culture conditions - evolutionary engineering
- High-cell-density cultures using perfusion - process intensification
- Stable insect Sf9 cell lines for influenza HA-VLPs production
Antonio Roldao
iBET
iBET
1530 - 1600 CELL-FREE SYNTHETIC SYSTEMS FOR SCALABLE AND TIMELY VACCINE MANUFACTURE
- Requirements for rapid scale-up and deployment of vaccines has accelerated the maturation of cell-free systems as an approach for commercial biologics supply
- Opportunities afforded by such an approach as well as the challenges to be overcome to improve its more widespread adoption
- Case studies to illustrate the points raised and share learnings from the work at CPI
Philip Probert
Centre for Process Innovation Limited
Centre for Process Innovation Limited
1600 - 1630 ULTRAIPV, AN IMPROVED INACTIVATED POLIO VACCINE
- Attenuated strains are used as a way of reducing the biohazards associated with the production of neuropathogenic WT strains
- Developing a novel complex that is mixed with the virus to protect amino acids from damage associated with ultraviolet light
- Understanding this quick, inexpensive, and simple method that is gentler to the neutralizing epitopes than formalin resulting in reduction of cost of goods and may reduce potential shortages
Gregory Tobin
Biological Mimetics, Inc.
Biological Mimetics, Inc.
1630 - 1730 NETWORKING DRINKS RECEPTION
DAY 2: WEDNESDAY, 30 JUNE, 2021
0900 - 0930 MORNING REFRESHMENTS
0930 - 0940 OPENING ADDRESS
0940 - 1010 DEVELOPMENT OF 2ND GENERATION HIGH POTENCY & MULTIVALENT SARS-COV2 VACCINE CANDIDATES
- Enveloped virus-like particle vaccines are customizable and elicit potent neutralizing responses
- Preclinical data demonstrate highly potent neutralizing responses and protection from challenge with SARS-CoV2
- Clinical evaluation is underway with data expected mid-2021
Francisco Diaz-Mitoma
VBI Vaccines Inc.
VBI Vaccines Inc.
1010 - 1040 GENOME EDITING OF AVIAN HERPESVIRUSES FOR RECOMBINANT VACCINE DEVELOPMENT
- Introduction of Marek’s disease vaccines and traditional ways for making recombinant HVT vectored vaccine
- Generation of trivalent HVT vectored vaccine using CRISPR/Cas9 system
- Characterization of trivalent recombinant HVT vectored vaccine
Yongxiu Yao
The Pirbright Institute
The Pirbright Institute
1040 - 1100 MORNING COFFEE BREAK IN EXHIBIT AREA
1100 - 1130 NEXT GENERATION SARS COV-2 T-CELL VACCINE USING AN INTRANASAL NANOPARTICLE DELIVERY SYSTEM AND GENE BASED IMMUNODULATORS
- Elicits T-cell responses with the potential to last for 10 or more years
- Delivered intranasally to elicit local immunity in the airways and lungs, sites of viral entry and infection where first-line potent, long-term resident T cell memory responses are most critical
- Deliver a gene-based immunomodulator that stimulates trained innate immunity to ‘turbocharge’ potent and durable T cell memory responses to vaccination
Tom Tillett
MBF Therapeutics
MBF Therapeutics
1130 - 1200 ROLE OF PRODUCT DEVELOPMENT PARTNERSHIP IN ACCELERATING VACCINE DEVELOPMENT: EXPERIENCE FROM IVI’S TYPHOID PROGRAM
- PDPs play critical role to move the neglected disease vaccine agenda forward
- Multiple complex interrelationships affect vaccine development
- Experiences from 4 countries, 5 clinical trials from IVI’s typhoid program
Sushant Sahastrabuddhe
International Vaccine Institute
International Vaccine Institute
1200 - 1230 MVX01: A SEROTYPE-INDEPENDENT PNEUMOCOCCAL PROTEIN FUSION VACCINE CANDIDATE
- Pneumococcal PLY toxoid fused to CbpA epitopes
- MVX01 protection conferred from 17 or 20 Virulent pneumococcal serotypes
- Superior to Polysaccharide Capsular Vaccine (PCV); Synergistic with PCV
- cGMP material produced
Kevin Killeen
Matrivax Corporation
Matrivax Corporation
1230 - 1400 NETWORKING LUNCH & RAFFLE DRAW
Key topics for 2021:
- The fundamentals of new vaccine discovery and development
Understand biotech and pharmaceutical industry fundamentals and key market drivers for developing vaccinations from a global perspective. - Exploring new technologies in vaccine delivery for better immune responses
Look for new opportunities and make the clinical case for adopting new technology and techniques for vaccine delivery. - Latest research in genetically-engineered vaccinations and mRNA vaccine technologies
Explore new innovations and assess the latest results from tests and trials in biologically-engineered vaccinations, as well as new advancements in DNA, messenger RNA vaccination technologies. - New developments in viral vectors, nucleic acid-based vaccines, and structural vaccinology
Future of vaccination strategies and the latest advancements in viral vector-based applications for adapting structural viral vaccine design and development. - Advances in live-attenuated virus vaccines and lessons learnt from inactivated vaccines
Hear from leading vaccine developers and build on traditional vaccine approaches for cost-effective and proven methods for developing new vaccines. - Case studies and clinical trials and working with global vaccine manufacturers
Gain insight from leading manufacturers and implement strategies that others in the industry are using to ensure successful vaccine delivery.
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